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10.1016/j.jinorgbio.2003.10.021 23 HerrC

Their structure is based on the generic structure of flavonoids, a flavan nucleus formed of two aromatic rings linked through a dihydropyrone ring (2,3-dihydro-2-phenylchromen-4-one)

However, it should be taken into account that although the difference in the pKa values of the two acidic groups of 4-hydroxythalidomide is sufficient to ensure selective alkylation of the phenolic group, a reaction may still occur in the imide nitrogen zone given its adequately acidity