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The 8-hydroxy-2-deoxyguanosine (8-OHdG) is a modification product resulting from oxidative DNA damage induced by ROS

In the modeled PI(3,5)P 2 -bound AtCLCa structure, the inositol head group coordinated by one protomer is at the vicinity of the cytoplasmic H + outlet of the other protomer, and the free C3-phosphate of PI(3,5)P 2 points to the proton glutamate Glu270 (Fig