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Potential consequences of vitamin B12 can vary and requires diagnosis by a medical health care provider and include (11, 13, 14): Fatigue and weakness: Vitamin B12 is essential for energy metabolism, and deficiency can result in fatigue, weakness, and lethargy due to impaired production of red blood cells and energy

PMID:30692251

Limitations of the therapeutic use of superoxide dismutase Due to the instability, high immunogenicity, low cellular uptake and less in vivo circulation of the half-life of superoxide dismutase, their clinical use as therapeutic agents is very limited

Inflammatory Acne or Rashes Although uncommon, a deficiency in B12 may lead to: Persistent acne-like eruptions Seborrheic dermatitis-like rashes (scaly, red patches, especially around the nose or scalp) Increased skin sensitivity and redness Some people experience inflammatory breakouts due to an imbalance in the skins bacterial profile, worsened by low B12 levels

Otherwise, the safety profile appears favorable across most populations