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Rational design is not widely used, except for P5, PRG-RADA16, and RK81 QTY [97,130]

299 SaitohA.SuzukiS.SodaA.OhashiM.YamadaM.OkaJ

The peptide addresses joint conditions (arthritis and chronic joint pain) by decreasing synovial inflammation and limiting cartilage degradation in affected joints

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It remains to be further investigated, whether it is possible to avoid blunting of the inhibitory action by other types of inhibitors, by their combination or by combination of the diverse therapeutic modalities to efficiently limit propagation of tumor cells