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All the authors approved the final version of the manuscript

A 2016 study published in Nature Medicine demonstrated that MOTS-c administration improved insulin sensitivity and reduced diet-induced obesity in mouse models, even when started after metabolic dysfunction was already established

Compounds with a short half-life, like insulin, apelin-13, ginsenoside Rg3 and cyclin D1 may achieve better bioavailability and expedited onset of action following intranasal administration