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NADPH is a critical reductant produced during immune metabolism, maintaining the function of intracellular antioxidant systems (e.g., thioredoxin and glutathione systems) and bidirectionally regulating ROS production and clearance in certain cells such as macrophages 143,144,145,146

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Am J Respir Cell Mol Biol 39(6):697705 Kinnula VL, Fattman CL, Tan RJ, Oury TD (2005) Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy