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Lorenzini L, Fernandez M, Baldassarro VA, Bighinati A, Giuliani A, Calz L, Giardino L (2020) White Matter and Neuroprotection in Alzheimers dementia

ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis

When the peroxidation of a PLOOH molecule is not catalyzed by glutathione peroxidase 4 (GPX4) to form the corresponding alcohol (a PLOH), the PLOOH and lipid radicals, especially PLOO and alkoxy phospholipid radicals (PLO), continue to drive the dehydrogenation of PUFA-PLs and to react with oxygen through the Fenton reaction to generate a large number of PLOOH molecules [5, 15, 44, 45]

Valko et al., 2007

In contrast, mixture-exposed males had lower hepatic GSH/GSSG levels, suggesting oxidative stress