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Sodium acetate trihydrate was added to facilitate product formation

The phosphorylation level of CRMP2 is significantly higher than in controls, severely inhibiting the regeneration capacity of neuronal axons (Arimura et al., 2005)

These preclinical studies in a -thalassemic mouse model generated the rationale for a phase II proof-of-concept study (ClinicalTrials.gov NCT03692052) of mitapivat in patients with nontransfusion-dependent thalassemias (NTDTs), including both - and -thalassemia genotypes