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Leyden J, Dunleavy K

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[166] found that the consequence of upregulation of TNF- due to lipopolysaccharide (LPS) stimulation could be blocked by SAMe, MAT, or SAH pretreatment, through increasing the binding of H3K4 to the TNFA promoter

10.1038/s41418-024-01286-6 195 SongX.ZhuS.ChenP.HouW.WenQ.LiuJ.et al (2018)

In ASD management, blood testing also aids in evaluating the impact of supplements on metabolic pathways