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Although preclinical studies have shown promise, there is a lack of comprehensive clinical data on the efficacy, safety, and optimal dosages of natural compounds in PD patients

Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the calcium-dependent transamidation reaction between glutamine and lysine residues of proteins to form crosslinked proteins

Preclinical studies suggest it promotes angiogenesis (new blood vessel formation), collagen synthesis, and modulation of nitric oxide pathwayskey steps in tissue repair

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It is produced in the liver and plays a crucial role in maintaining overall health