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Shifting to every-other-day administration during weeks 46 reduces cumulative receptor occupancy and slows further desensitization while still maintaining therapeutic plasma IGF-1 LR3 levels, extending the effective anabolic window by 12 weeks compared to continuous daily dosing that plateaus completely by week 5

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Therefore, local application of NIR laser irradiation can trigger rapid release of SB and DOX in tumor tissues, which enables synergistic anti-tumor therapy of DOX and SB to significantly improve anti-cancer outcomes

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These bigwigs, along with the previously obtained induced and reduced peaks in bed format, were input into deeptools computeMatrix, and the output was plotted using deeptools plotHeatmap reference-point