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Their work demonstrated that NRN1 not only promoted human umbilical vein endothelial cell migration but also enhanced tumor-associated angiogenesis in vivo , supporting its contribution to pathological neovascularization (Yang et al., 2021)

In addition, during the process of pulmonary fibrosis, the upregulation of the fibroblast vitamin D receptor can be regarded as a self-protection mechanism of the body, because it can effectively limit the proliferation and activation of fibroblasts by inhibiting the JAK1/STAT3/ER stress pathway, thereby affecting the development process of pulmonary fibrosis (174)

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