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Abstract Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the worlds poorest children and women of childbearing ages across regions of sub-Saharan Africa

To address this, we additionally deleted the gene coding for Ggt in these cells and analyzed reduction of Grx1-roGFP2 by exogenous GSH in the resulting gshA gsiC ggt triple deletion mutant

Improving the supply of raw materials for GSH systems The direct administration of GSH in vivo is probably an obvious way to increase GSH It has been demonstrated that modified oral glutathione-like liposomal GSH increases erythrocyte and plasma GSH levels and reduces oxidative stress biomarkers [98]

Endogenous redox sensors ( e.g

Adulteration with synthetic drugs (e.g., corticosteroids in anti-diarrheal preparations) or contamination with heavy metals and pesticides further undermines safety