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We list it as our high-potency pick for two specific scenarios: anyone with documented deficiency working to replete liver stores, and anyone whose absorption is significantly compromised (long-term metformin + PPI combination, post-bariatric surgery, atrophic gastritis on biopsy)

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For example, acyl-CoA oxidase (three isoforms - ACOX1, 2 and 3), the first enzyme in peroxisome oxidation transfers hydrogen to oxygen to make H 2 O 2 while carrying out a dehydrogenation reaction for the first ,-unsaturated intermediate, trans -2-enoyl-CoA