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Among biomarkers of oxidative stress, the ratio of reduced glutathione (GSH) to glutathione disulfide (GSSG) is frequently measured in various cell types, owing to the millimolar intracellular concentrations of these glutathione species and the broad availability of assays for their measurement, including many that are commercially available 1,3,4

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Exp Biol Med (Maywood) 227(10):852859

But, if the gap doesnt seal, stomach contents may pass back through and enter the esophagus