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Although low serum B12 levels have been associated with increased bone turnover and fracture risk (9) , long-term B12 and folic acid supplementation did not improve bone mineral density (38) , or reduce osteoporotic fracture incidence in elderly individuals with elevated plasma homocysteine levels (39)

Oxidative DNA damage is mainly caused by ROS, a complex process involving multiple reactions controlled by a combination of enthalpy, entropy, steric hindrance, and its constituent factors, as well as charge reactions and transport (7) ( Figure 1D )

doi: 10.1074/jbc.M510644200 54 KimY

Another immunomodulatory microbial metabolite is tryptophan-derived indoles, which activate the aryl hydrocarbon receptor (AhR) on astrocytes and intestinal immune cells [72]