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The simulated effect was computed of a dose of CLP257 and a dose of L838,417 is thus given by: Equation 11 was used to generate the distinct effector modeled surface in Fig

Safety: Vitamin B12 is generally considered safe, even at high doses, because excess amounts are usually excreted in the urine

There are rare case reports linking high-dose B12 supplementation to acne flares, possibly through effects on skin bacteria that produce inflammatory compounds