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The first line of defense prevents biomolecular damage by preventing the formation of free radicals and their derivatives, which involves the action of enzymatic antioxidants that catalyze the disproportionation of ROS, including superoxide dismutase (SOD), catalase (CAT), glutathione reductases (GRs), glutathione peroxidases (GPxs) and glutathione-S-transferases (GSTs)