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These results, in line with our previous in vitro and ex vivo results, confirm the therapeutic capacity of dyclonine and leucovorin to promote oligodendrogenesis in a model of preterm birth brain injury and validate the intranasal approach to administer these compounds and their capacity to cross the blood-brain barrier (BBB)

In transgenic AD models, exercise decreases pro-inflammatory cytokine expression, diminishes amyloid burden, and improves spatial learning (Mielke et al., 2025)

CD8+ T cells that have been activated express the receptor 4-1BB

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Curr Drug Targets 7(6):661668 Park MH, Hong JT (2016) Roles of NF-B in cancer and inflammatory diseases and their therapeutic approaches