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Functional Variants in the Glutathione Peroxidase-1 (GPx-1) Gene Are Associated with Increased Intima-media Thickness of Carotid Arteries and Risk of Macrovascular Diseases in Japanese Type 2 Diabetic Patients

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The flux of a given substrate to oxidative pathways is largely dependent on the expression and the activity of rate-limiting enzymes that are respectively modulated by transcriptional and post-translational processes, which are under the control of many intertwined signaling pathways including pathways regulated by vitamins, as will be detailed later

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