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Protocatechuic acid protects against thioacetamide-induced chronic liver injury and encephalopathy in mice via modulating mTOR, p53 and the IL-6/IL-17/IL-23 immunoinflammatory pathway

Therefore, the decomposition of HMPB in an acidic environment releases exogenous iron for the production of toxic hydroxyl radicals, coupled with the targeting and photothermal destruction of ferritin in a neutral cytoplasmic environment, thus collectively constituting a synergistic process

Methods A comprehensive literature search was conducted across PubMed, Web of Science, Embase, and the Cochrane Library for articles published from inception to August 2025

This result is in excellent agreement with data by Gregus and Klaasen who reported that following single IV injection of 1 mg Co(II)/kg 72.6% of non-radioactive cobalt was excreted in urine by day 4.(26) Fecal excretion peaked at 3.3% at day one post exposure and gradually reduced to 0.5% atday5