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System x C blockade targets cancers with mut-p53 accumulation Since cancer cells with mut-p53 accumulation are vulnerable to oxidative stress, we next sought to identify potential antioxidative stress genes which when suppressed, would preferentially kill cancer cells with stabilized mut-p53

Glutathione, oxidized (GSSG): This is the oxidized form of glutathione, produced when two glutathione molecules are linked by a disulfide bond

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Inhibition of the first rate-limiting enzyme of one-carbon metabolism (PHGDH) has been shown to promote cell growth arrest, a phenomenon that occurs as a result of an accumulation of intracellular reactive oxygen species (ROS) following the inhibition of glutamine metabolism

10.1016/j.neuroscience.2009.01.021 Neuroscience 135 WeiZ.TongguangW.ZhongP.MillerD