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Cellular swelling, karyolysis, karyorrhexis, vacuolization, release of cellular contents, endoplasmic reticulum stress, sterile inflammation, and autophagy are other mechanisms associated with APAP hepatotoxicity

To summarise, ageing is accompanied by significant decline in astrocytic haemostatic and neuroprotective capacities, which may directly affect nervous tissue and increase it vulnerability to pathological attacks and neurodegeneration

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Signs of photoaging include wrinkles, decreased elasticity, and pigmentation changes such as age spots, sun spots, and freckles