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doi: 10.1038/nrd3793

Evidence indicates that an altered BBB contributes to iron accumulation, particularly in substantia nigra and striatum, and neuroinflammation in PD models

Therefore, more effective interventions to prevent the development of DKD are urgently needed

The approved-pathway comparison points remain tirzepatide (Mounjaro/Zepbound) on its own and the investigational CagriSema (cagrilintide + semaglutide)

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