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Paget, Lectures on surgical pathology delivered at the Royal College of Surgeons of England, London

High levels of ROS, such as superoxide anions (O 2 ) and hydrogen peroxide (H 2 O 2 ), originate from the electron transport chain and, to a lesser extent, following catalysis by cytosolic and plasma membrane oxidoreductases (Nolfi-Donegan et al

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Lu J, Wang C, Cheng X, et al

354 In contrast, familial neurodegenerative disorders, such as inherited PD, often benefit from sustained autophagy activation as a result of persistent proteotoxic stress, whereas sporadic cases may show variable responses depending on the metabolic state and disease progression