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62 , 63 The correlation between the different biochemical variants, the site of genetic mutation, and the extent of hemolysis is a matter of current investigation

Klap J, Schmid M, Loughlin KR

Genetic polymorphisms in the HNMT gene have been associated with altered histamine sensitivity, and factors that inhibit HNMT (including certain MAO inhibitors and alcohol) can compound histamine accumulation at the cellular level