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4.1 Re-evaluating therapeutic approaches in AD For years, the amyloid cascade hypothesis has been the dominant framework guiding AD research

The dsRNA replicative intermediate is a potent pathogen-associated molecular pattern (PAMP) sensed by pattern recognition receptors (PRRs) in the cytoplasm (RIG-I-like receptors (RLRs)) and the endosome (Toll-like receptor 3 (TLR3))

Moderate Alcohol Consumption Uniquely Regulates Sodium-Dependent Glucose Co-Transport in Rat Intestinal Epithelial Cells In Vitro and In Vivo

To further expound on the fire metaphor, the result of not being able to neutralize the effects of ROS, is damage and, also, inflammation (literally the body is in flames)

Less immune-cell infiltration into the postischemic area suggested either that Fer-1 directly inhibits leukocyte transmigration or that the local proinflammatory microenvironment was less chemoattractive, presumably by less damage-associated molecular pattern (DAMP) release due to less ferroptotic cell death