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Cycle structure IGF-1 LR3 Cycle Structure Approach Conservative On-cycle 3-4 weeks Off-cycle 4-6 weeks Best for Lower-dose tolerance assessment in first cycles

Table 2 Statistically significant differences in genes compared between tumours with low and high LEF-1 expression in the cohort described in Table 1 based on Nanostring nCounter

Smoking status was categorized as never, former and current smokers

NAD+ Nicotinamide adenine dinucleotide (NAD+) is a coenzyme involved in cellular energy production and DNA repair

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