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25,211,492 In addition to targeting fragile X syndrome, mGluR5 inhibition has been shown to salvage many phenotypes, including learning and memory deficits, social deficits, repetitive behaviours, hyperactivity, and dendritic spine dysmorphogenesis, in 16p11.2 deletion mice, BTBR mice and Shank3- knockout mice

however, no corresponding fall in AChR autoantibody titer was observed (125)

Statements Author contributions LW, PL, PiL: conceptualization

Fibrous astrocytes are highly prevalent in white matter, have long non-branched processes with endfeet involved in Ranviers nodes