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This highly purified, stable tripeptide structure has been clinically proven to survive the digestive tract far better than generic forms

In addition, melatonin upregulated the Bcl-2, sirtuin 3, and FOXO type 1 gene expression, as well as downregulated the Bax and caspase-3 gene expression

Crit Rev Toxicol 23:2148 Diplock AT, Rice-Evans AC, Burton RY et al (1994) Is there a significant role of lipid peroxidation in the causation of malignancy and for antioxidants in cancer prevention