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Number and rate (per 1,000 person-years) of lung cancer deaths by number of cigarettes smoked per day, Doll and Hill physician cohort study, Great Britain, 1951-1961

MtDNA methylation determination For mtDNA methylation measurements, mtDNA isolated from the TRIzol RNA phase [44] was digested by HindIII (Thermo Scientific, USA), with cutting sites located in MT-CO1 , MT-ND4 and MT-ND5 , which are outside the assessed DNA regions (Suppl