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doi: 10.1038/s41586-020-2229-5 51

Pagnotta S, Tramutola A, Barone E, Di Domenico F, Pittal V, Salerno L, Folgiero V, Caforio M, Locatelli F, Petrini S, Butterfield DA, Perluigi M

If I had a patient with a massive heart attack and lets say had pump function or rejection fractures of 10-15%, if I gave that patient metabolic cardiology and they lived another 5 or 10 years, now their own intrinsic stem cells would take over and replace their damaged heart cells with new heart cells

Considering these pathways, flavonoids may be therapeutic candidates for asthma, not only for their protective effects as antioxidants but also for their modulatory effects on cell signaling cascades related to inflammation and lung pathology (103)

Key structural alterations include disrupted mitochondrial morphology, severe ultrastructural damage, and depletion of mitochondrial DNA (mtDNA)