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Bacterial species most often observed to be over-represented in CRC from these studies include Fusobacterium nucleatum (Fn), Enterococcus faecalis, Streptococcus gallolyticus ( SGG) , enterotoxigenic toxin producing Bacteroides fragilis (ETBF) , and Porphyromonas species ( Roseburia, Ruminococcus, Clostridium, Faecalibacterium and Bifidobacterium are generally depleted in CRC patients ( ks (polyketide synthase)+ Escherichia coli (pks+Ec), ETBF , Fn , and SGG , damage the gut-barrier lining and colonocyte DNA, increase proinflammatory cytokines and oxidative factors, and produce potentially carcinogenic toxins (61)

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Ellul P., Maruani A., Vantalon V., Humeau E., Amestoy A., Anchordoqui A., Atzori P., Baleyte J.M., Benmansour S., Bonnot O., et al

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It binds to copper, influencing gene expression to activate vital functions that improve skin texture, support hair follicle health, aid in healing, and reduce inflammation

Tomita S, Stein V, Stocker TJ, Nicoll RA, Bredt DS (2005b)