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Blood Vessel Damage Concerns over long-term exposure of Nexium surfaced once again when a study published in May 2016 in the Circulation Research raised questions about faster aging of blood vessels due to PPIs like Nexium

Contact your GP if you experience: No improvement after 46 weeks of treatment : Whilst neurological symptoms may take longer to resolve, you should notice some improvement in energy levels or general wellbeing within this timeframe

doi: 10.3390/jcm8101645

the latter might be implicated in the total and resting energy expenditure reduction seen after weight loss

Still, it is worth being aware of the possibilities, especially if you have certain pre-existing conditions