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Unlike muscles that enjoy rich vascular networks, tendons depend on a sparse collection of blood vessels that struggle to deliver the oxygen, nutrients, and growth factors needed for repair

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For example, in various cell culture lines, c-Met phosphorylation can result in downstream activation of Akt, Erk/MAPK, JNK, or FAK signaling (reviewed by Organ and Tsao, 2000

doi:10.1016/j.joca.2006.07.002 259

By enhancing hepatocyte growth factor (HGF) activity at c-Met receptors, DIHEXA promotes neural plasticity and the formation of new synapses