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The epidemiological finding that other autoimmune illnesses have comparable "epidemics" shows that environmental variables other than gluten may be involved

Recently, several peroxisomal proteins, such as LonP2, insulin-degrading enzyme, and PEX11, have been suggested to contribute to the maintenance of peroxisomal redox homeostasis, similar to the abovementioned antioxidants 34,35,36

Dysfunctional endothelial nitric oxide synthase can further promote ROS production, which exacerbates endothelial damage by reducing NO synthesis and secretion

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This important review discusses the implication of mass deworming programmes on the potential emergence of inflammatory and metabolic conditions in developing countries that are ill-equipped for these new epidemics