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Moreover, some agents that have been used to interfere with p53 function are peptide-based, which would render them difficult to apply for brain senescence

This convergence of evidence underscores a shared pathophysiological thread where dysregulated microglial activity drives neural circuit dysfunction, making its pharmacological inhibition a rational cross-disease therapeutic approach

Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles