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However, as soon as ferrochelatase has inserted iron into protoporphyrin IX (the end product of porphyrin synthesis), iron leaves the mitochondria again, now being part of the heme molecule

Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and -catenin

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