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First, mechanistic studies should combine single-cell spatial transcriptomics with mitochondrial metabolomics to map ferroptosis pathways in spinal ventral horn motor neurons, microglia, and astrocytes, with emphasis on the coupling between NCOA4-mediated ferritinophagy and SOD1/TDP-43 clearance, thereby establishing a dynamic model linking mitochondrial iron dysregulation, proteotoxic stress, and cell death

4 , 9 Consequently, drugs that inhibit this enzyme (e.g., amiodarone, co-trimoxazole, metronidazole and fluvoxamine) potentiate the effect of warfarin and necessitate a lower warfarin dose for most patients

90Y-DOTATOC dosimetry-based personalized peptide receptor radionuclide therapy

2-DE separates proteins into multiple spots based on their isoelectric point and molecular weight, whereas Western blotting (WB) detects the total amount of the entire protein

10.1016/j.neuron.2019.05.035 Neuron 168 KitadaT.AsakawaS.HattoriN.MatsumineH.YamamuraY.MinoshimaS.et al (1998)