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Vitamin D deficiency is common in intensive care unit (ICU) patients (50 - 82%) and is associated with multi-organ dysfunction

It prevents aging, cardiomyopathy, dementia, cancer, and different chronic diseases

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Among the overlapped pathways (Supplementary Table 2), twenty-seven pathways, such as Hippo signaling pathway, TGF- signaling pathway, Wnt signaling pathway, tight and adherens junction, were up-regulated in APAP but down-regulated in CON and APAP_BSL