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Concentrations decline sharply with age: plasma levels drop from roughly 200 ng/mL at age 20 to under 80 ng/mL by age 60

For example, synthetic neuroactive steroids bearing a hemisuccinate group are more resistant to hydrolysis than the corresponding sulfate esters and are partly unionized at physiological pH, allowing increased passage across the BBB

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Our data was consistent with a previous result of DHEA concentration was reduced in CNS tissues from patients with MS and in animals with EAE (122)

"PD18-04 Urolife and Rezum: A Comparison of Device Related Adverse Events in a National Registry"