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This mechanism explains why testosterone therapy may cause testicular atrophy, and decreased sperm counts during treatment

10.1007/s00415-021-10657-9 298 LuoJ.LinS

Indeed, Cl channels and Cl transporters also help regulate -cell membrane potential and excitability, both crucial for insulin release (Best et al., 2010)

To this regard, Mumford et al

This stabilizes the transcription factor BACH1, which subsequently upregulates angiogenesis-related factors, including PDGFB, EGFR, FGF2, and FGFR1, ultimately driving vascular regeneration