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This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery

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Biol Trace Elem Res 195:499505 [DOI] [PubMed] [Google Scholar] Friedman B, Cronstein B (2019) Methotrexate mechanism in treatment of rheumatoid arthritis