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Further, the presence of astrocytic cytoplasmic inclusions, protein aggregates like alpha-synuclein (SNCA), A, and Tau in neurons, can also contribute to neuropathology (Li and Haney, 2020) and appears to be one of the critical features in many neurodegenerative diseases

These processes are key to AGE formation and introduce carbonyl groups into the side chains of proteins, particularly nucleophilic lysine and arginine groups

The New EU HTA Framework Creates New Evidence Requirements Since becoming applicable in January 2025, the EU Health Technology Assessment (HTA) Regulation has significantly increased the focus on patient-centered outcomes and real-world evidence as key components of reimbursement, market access, and healthcare decision-making across Europe

Retrospective observational study on riboflavin prophylaxis in child and adolescent migraine

6 and 7 ) exhibited different spectral bands, clearly indicating the presence of two different crystalline forms