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In some cases, pathogenic mutations are observed in genes associated with the CoQ10 biosynthesis (primary CoQ10 deficiencies) or those not directly associated with CoQ10 biosynthesis (secondary CoQ10 deficiencies)

The activation of specific proteins, such as C/EBP homologous protein (CHOP), plays a crucial role in mediating apoptosis during ER stress

While the value of the NLR needs to be reproduced in other populations, it is a cheap and readily available biomarker that could be readily deployed in clinical practice

Using a similar process, the risk of bias for intervention trials included in the review omitting the case report [54] was assessed using the criteria set out in the Cochrane Collaboration Handbook [55]

Plant Physiol 169:29632981 De Vos CHR, Vonk MJ, Vooijs R et al (1992) Glutathione depletion due to copper-induced phytochelatin synthesis causes oxidative stress in Silene cucubalus