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Figure 2 Limitations and future prospects Despite its microbial richness, propolis intervention did not alter plasma levels of uremic toxins such as indole-3 acetic acid, p-cresyl sulfate, and indoxyl sulfate, nor did it significantly change gut microbiota composition ( Bifidobacterium and Blautia spp.) and reduced eGFR, further studies are needed to clarify their impact on kidney function ( Probiotics also showed limited efficacy

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People carrying reduced-activity variants tend to clear food-derived histamine more slowly, which is why high-histamine meals aged cheese, cured meats, fermented foods, wine can trigger reactions

7 Dysregulation typically results from mutations in pathway components or altered expression of Wnt ligands and receptors

However, not everybody lives a healthy lifestyle and eats a balanced diet