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In this study, adults that were either obese or overweight with one weight associated condition were randomized to get subcutaneous retatrutide at various doses or placebo for a period of 48 weeks

Tirzepatide and semaglutide have different receptor profiles, potencies, and dose ranges

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J Exp Bot 61:473482 Dubreuil-Maurizi C, Vitecek J, Marty L, Branciard L, Frettinger P, Wendehenne D, Meyer AJ, Mauch F, Poinssot B (2011) Glutathione deficiency of the Arabidopsis mutant pad 2-1 affects oxidative stress-related events, defense gene expression, and the hypersensitive response

PMC2730961