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Mitoglitazone group (Mito): mice were given 10 mg/kg/day mitoglitazone orally daily parallel with MASH induction protocol for 12 weeks

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In a transgenic mouse expressing low GSH levels (Gclm KO), we found reduced number of prefrontal and hippocampal PV-immunoreactive interneurons together with diminished high-frequency neuronal synchronization [81, 82], reduced number of PV-immunoreactive neurons in thalamus reticular nucleus together with altered firing properties [56], thus demonstrating the functional consequence of a redox dysregulation