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c-Met PI3K/Akt MAPK/ERK, ,

Studies have demonstrated that Hinge binds to HGF with high affinity blocking its dimerization and acting as a potent inhibitor of HGF-dependent cellular activities including MDCK D-Nle-X-Ile-NH-(CH 2 )s CONH 2 analogs modify HGF/Met mediated cell scattering in MDCK cells HGF/Met signaling is the hallmark effect of HGF/Met signaling