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Further research should focus on conducting more clinical trials targeting specific OA subtypes (e.g., inflammatory OA) and investigating the combined use of TNF and IL-6 inhibitors with other therapies, such as stem cell therapy and chondroprotective agents

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Zeidan F, Baumgartner JN, Coghill RC (2019) The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer

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When this structure is in place, the impact becomes measurable